Science is humanity’s best weapon against disease. At Ossium, we are harnessing previously untapped resources for life-saving bone marrow stem cells to fight blood cancers, improve organ and limb transplantation, repair cellular damage from radiation poisoning and other applications.
Patient Medical Need

Roughly 20,000 new U.S. patients go looking for a bone marrow transplant each year, but only 30% have a relative who matches. Of the remaining 14,000 patients, fewer than 5,000 receive transplants from unrelated donors. The living donor bone marrow registry, autologous bone marrow transplants, and umbilical cord blood banks have provided lifesaving solutions for thousands of patients with hematologic diseases. However these methods still suffer from severe limitations driven by the scarcity of matched bone marrow.

14000
Annual U.S. Patients Seeking Unrelated Donor
5000
Actual U.S. Unrelated Donor Transplants Performed
9000
Unmatched Patients
Increased availability of bone marrow

Ossium Health aims to establish a new complementary source of life-saving, on-demand, off-the-shelf bone marrow stem cells for clinical use — through recovering bone marrow from deceased organ and tissue donors to build a global bank. This will dramatically increase the availability of matched bone marrow and enable clinical use of a vast, untapped source of these lifesaving stem cells.

History of bone marrow transplantation

Bone marrow has been used for decades to treat numerous life-threatening diseases. New technology is making it possible to use bone marrow in ways never before possible. Although hearts, livers, kidneys and lungs are routinely recovered from donors to save patients waiting for transplants, the bone marrow from these same donors has gone unused. Ossium Health has developed proprietary technology to efficiently recover and cryopreserve bone marrow from organ donors to make this important clinical resource available worldwide.

Hematopoiesis

Hematopoietic stem cells (HSC), which primarily exist in the bone marrow, are derived from the mesodermic germ layer and are responsible for providing new blood and immune forming cells throughout your life.

Where bone marrow lives

Bone marrow is found mainly in the flat bones such as the hip bone, breast bone, skull, ribs, vertebrae and shoulder blades, and in the cancellous (“spongy”) material at the proximal ends of the long bones, femur and humerus.

Human Leukocyte Antigen (HLA) Matching

When something goes wrong with your bone marrow, aggressive action is required. In cases of malignancy or other severe disease, a bone marrow stem cell transplant may be needed. These stem cells must be carefully matched to allow a patient to develop a new blood and immune system without the new immune system rejecting the recipient’s body (called graft vs. host disease).